UCL HUNTINGTON’S DISEASE RESEARCH
MULTIPLE TISSUE MOLECULAR SIGNATURES IN HUNTINGTON’S DISEASE (MTM-HD)
From research in HD and other human diseases there is growing evidence that the same mechanisms of disease may be shared between the brain and peripheral tissues. In HD the mutant protein is expressed in almost all cells.
Data generated from multiple tissue analysis can be used to construct molecular networks that are dynamic and more representative of a disease state. Furthermore, molecular networks may help identify markers of disease progression but also markers of resilience, and generate drug targets.
We plan to collect muscle, skin, blood and fat samples from pre-manifest HD gene carriers HD subjects and matched controls, undertaking state-of-the-art molecular analysis to establish molecular networks.
We envisage a start date in 2013.