UCL HUNTINGTON’S DISEASE RESEARCH
HD BIOMARKERS PROJECT
At a glance
Involves blood tests
About the study
There are lots of potential treatments for HD that need to be tested. But it is very difficult to determine how effective a therapy is being over time, because the clinical examinations we use in patients are not sensitive enough to pick up significant changes over short time periods.
So, finding other markers such as blood tests, brain scans or clinical tests, that could also be used to track disease progression would be very useful. Ways of monitoring the disease more accurately, in ways that reflect what is happening to brain cells, are crucial for the monitoring of therapies that will slow the disease.
We call these measures biomarkers and at the moment, there is no single test or combination of tests that accurately measures and predicts the progression of HD.
In addition, markers capable of detecting changes in patients who have the HD gene but do not yet have any symptoms of the disease (carriers), will be essential to decide when to start treatment to delay progression and in monitoring their success.
The Queen Square biomarkers project has already collected one of the largest and most important libraries of blood and urine samples from HD patients and their families. The samples are shared with collaborators in the UK and abroad to identify and evaluate protein, metabolic, genetic and other biomarkers.
What is involved
The biomarkers project involves giving about 50ml (three tablespoonfuls) of blood. We collect specimens annually from patients who are already enrolled, as well as some new patients.
The blood test is just like any other blood test you may have had for clinical reasons, and can be done at the HD Multidisciplinary Clinic. Your blood and urine is not tested for anything that we already know to be of importance, so you will not receive a ‘result’ from the test.
Some subjects will be invited to donate cerebrospinal fluid (CSF) through a procedure called a lumbar puncture. Fluid is collected using a fine needle through the skin at the base of the spine. Local anesthetic is used to numb the area beforehand. The procedure takes about 30 minutes. Around 5-10% of people get a headache afterwards, which usually settles within a day or two.
Who can take part
To take part in the HD biomarkers project, you must:
- Be a patient of the NHNN Multidisciplinary HD Clinic
- Be aged 18 years or older
- Be willing and able to give blood samples
Who cannot take part
Patients with some medical conditions, or taking certain medications that may interfere with the tests, cannot take part in the HD Biomarkers project.
Find out more
|Contact the study team for more information:
Miss Nicola Robertson
|You will need Adobe Reader to view information sheets. Click here to download it.|
Updated October 12, 2010