UCL HUNTINGTON’S DISEASE RESEARCH
NEUROENDOCRINE STUDY OF HD
*PLEASE NOTE THIS STUDY IS NOW FULLY RECRUITED*
At a glance
Involves blood tests
Involve an MRI brain scan
About the study
Neuroendocrine HD aims to examine changes in hormones and metabolic factors at different stages of HD. Previous studies suggest that some features of HD including weight loss, sleep disturbances, mood changes and muscle loss may be caused by disruption of neuroendocrine systems.
This study hopes to identify potential biomarkers to monitor disease state and progression, which may represent targets for future clinical trials.
What is involved
Neuroendocrine HD involves a single visit to the Royal Free Hospital for a period of 24 hours (overnight stay in a private suite). The tests performed include a clinical examination, blood and urine tests, and a magnetic resonance (MRI) scan of the abdomen.
Who can take part
Neuroendocrine HD aims to recruit:
- 15 presymptomatic subjects who have had a positive gene test for HD but don’t have symptoms
- 15 patients who have had a positive gene test for HD and do have symptoms
- 15 control subjects (who do not carry the HD gene, including patients’ spouses, carers or relatives)
We are currently looking for volunteers from all of these groups so if you are interested in taking part or to find out more, please feel free to contact the study team.
|Contact the study team for more information:
Professor Tom Warner (Consultant Neurologist)
Royal Free Hospital, Pond Street
London NW3 2PF
Updated February 14, 2013